>>16952384
Perhaps the population is dysgenic; all these seemingly bad adaptations have not been selected for due to some obscure benefit and are simply a product of accumulating mutation unchecked by harsh Darwinian pressures that are currently restrained by complex civilization.

This is civilizations collapse. Civilization allows dysgenic breeding; eventually people are too stupid and ill to keep things running.

>>16952384
Are you retarded or something
Do you not understand that high blood sugar is what drives glycation?

>>16952405
>Do you not understand that high blood sugar is what drives glycation?
If you increase insulin sensitivity all you do is relocate this sugar from blood to cells. You decrease vascular glycation at price of increasing glycation in organs. You skipped biochem.

>>16952407
Blood stores glucose
Cells process it into other things like ATP and glycogen. I don't know the numbers but the burden of proof is on you to proof that intracellular concentrations of glucose ever come anywhere near blood levels, let alone stay that way for hours like they do with insulin resistance
Are you just having a schizo episode because you got diagnosed with diabetes? Be honest

>>16952404
They eat McD's every day. It's THAT simple.

>>16952409
>Cells process it into other things like ATP and glycogen.
Which generates many glycating chemicals, like methylglyoxal...
Read following papers regarding glycation and insulin resistance:
>An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition
https://link.springer.com/article/10.1007/s12551-024-01188-4
>Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes
https://pmc.ncbi.nlm.nih.gov/articles/PMC4338588/
>Are you just having a schizo episode because you got diagnosed with diabetes?
No, i don't have diabetes because my physical activity level is very high and i don't have much visceral fat. Just scientific curiosity.

>>16952422
Interesting
But the takeaway seems to be that it's best to manage diabetes by restoring insulin sensitivity naturally through exercise and fasting, which has always been my and I'm sure many others gut instinct
It's not like high blood sugar doesn't come with its own set of risks, that shit will make your arteries pop

>>16952384
insulin resistance doesn't exist, it's just misnamed

>>16952384
type 2 is due to bad covid infections retard

If you're resistant the sugar is going to damage your blood vessels by just sitting there. If there's excess fat and sugar in the blood the sugar is stored first.

>>16952384
Nigger, cells need glucose for the Krebs cycle and to make acetylcholine.

>>16952572
So keto causes dementia?

>>16952594
No, dementia causes keto

>>16952594
No, why would it? The body synthesizes glucose even if you're not ingesting it.

So what does it mean if you have hyperinsulinemia?