>>77208965
Starting dose in clinical trials is 2mg, target dose is 4/6mg. Half life is 6 days, takes about a month to reach optimal dose in body. You've been scammed, average price is 90-100$ for 100mg.

>>77208965
Sounds like you need to change industries and get a better job

>>77208965
Your receptors sensitize to it, that happens. I’m in contest prep and taking 10mg tirzepatide/3mg Retatrutide/2.5mg cagrilintide and I’m still fucking hungry.

Also you’re paying brutally Jewish prices for your peptides brother.

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>>77208965
Just stop eating carbs, bro. No need for drugs. Eat unlimited bacon.

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Nobody actually reads into the scientific literature on these GLP-1 peptides. They get their info from some tik tok dipshit or a faceberg glp-1 mom group who don't know shit about fuck.

You should avoid retatrutide if you're lean and insulin sensitive.

chronic GIP agonism from retatrutide without beta arrestin recruitment will perma fuck your hypothalamus' POMC neurons and ruin your leptin sensitivity.
Obese fatties already have chronically elevated GIP and leptin insensitivity.

Like how fat kids and adolescents can never truely get and stay lean in adulthood, their body fat set point is adjusted permanently higher.

tirzepatide is much safer since it has highly biased g protein recruitment at the GLP-1r and hgiher beta arrestin recruitment at GIPr whilst having much lower affinity for the GIPr relative to reta.

Of course the safest by far would be maridebart carfraglutide

>>77208965
Find a better vendor, you are getting scammed 10X wholesale markup. A kit that should last you a year at 8mg a weekbshould run under $300. If you primarily need appetite suppression get tirz which is even cheaper, $200 for 2 years worth. Check Glp1forum

maybe you shouldnt take experimental research substances

>>77208990
cico worked for me. keto has similar dumbass pictures.

the non troll answer is pick whatever works for you

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>>77209100
CICO caused the obesity epidemic. Before anyone heard of the calorie measurement they had no problems staying lean.

>>77208965
Why the fuck would you inject unknown chinese bathtub chemicals that don't work and aren't even reta when you could just eat high-satiety foods like cheeses and saturated fats with high protein?

>>77208998
anon your very knowledgable, so between sematutide, tirzapetide and retatutide, which one is least likely to fuck up a healthy person? And for an obese person, which one is best?

>>77209144
In the past people didn't care as much about eating less, if they got fat they changed eating habits not quantity.

If you are fat without eating any junkfood/fastfood, then something is seriously wrong with your lifestyle or diet.

>>77208965
Of a second I though this said "retarditide"

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>>77209322
Yeah people in the past intuitively knew that some foods are fattening (starch, sugar) and other foods are not fattening (butter).

Sugar Information Inc bamboozled everyone with flat calorie theory.

>>77209144
I just said it worked for me that's not really a retort to my point is it?

>>77208998
>chronic GIP agonism from retatrutide without beta arrestin recruitment will perma fuck your hypothalamus' POMC neurons and ruin your leptin sensitivity.
Does this applies to DPP-4 inhibitors?

>>77208965
so you did no research at all on how to dose this drug before you started taking it, did you?

>>77208990
Wild, because I ate 4000 calories a day on keto and got insanely fat, but restricting my calories to 2400/day with carbs included I got insanely shredded.

Almost as if....the calories in...must be less than the calories out....to lose weight

>>77209318
Semaglutide obviously wins out of the three since it lacks GIPr interaction completely. It could be better though since it's GLP-1r efficacy is actually lower than native GLP-1, but GLP-1 receptors recycle rapidly and you aren't doing any real harm taking it. The constant GLP-1 agonism appears to be a good thing.

Tirzepatide does have GIPr interaction, but it's affinity for GIP is way lower, has a lower Emax, much higher EC50, recruits less cAMP and more beta arrestin.
GLP-1r activation is protective and tirzepatide is also extremely g protein biased at the GLP-1r, reta is not.

For a healthy person, sema > tirz >>>> reta

For an obese person, their GIP is already chronically elevated, leptin sensitivity already fucked, POMC and AgRP/NPY fucked. Honestly reta probably wins here simply because it makes them drop the most weight overall, no other real reason

>>77209709
I doubt it.
But thats a good question, I haven't done very much research into DPP4 inhibitors compared to GLP-1 peptides.
My reasoning is: DPP4 inhibitors stop the breakdown of native incretins. Those incretins are pulsatile, only after a meal, and have less CNS penetration than GLP-1 based peptides. So you aren't getting constant GIPr activation 24/7 at supraphysiological levels, only physiologically stronger pulsatile release after meal time.

>>77208965
Are you people really taking drugs called Redarditall? Really?

>>77209971
Appreciate it amigo

>>77208998
>>77209971
Fuck me, I bought reta and didn't know that
I'm 18% bf, planned to start at 0.5mg/wk and up to 1mg/wk (max) over a month, and stay on it until cut to 10-12% is finished
Is 1mg enough to fuck my shit up? I'm considering just throwing it away

>>77210018
Well strangely enough the low and very low doses might actually be more dangerous than higher doses.

Reta is so strong at the GIPr, that by the time you've reached its EC50 concentration at the GLP-1r, you're already activating GIPr at >100% efficacy.

Additionally, the limited beta arrestin recruitment that does happen at GIPr doesn't happen until you hit higher concentrations.

(the GLP-1 agonism and GIPr beta arrestin recruitment are the protective mechanisms here)

Because of it's long ass half life, you're gonna be in this GIP activated without any protective mechanism zone for like 5 half lives after you cease taking it.

So if you do decide to take it, the amount of time you take it for matters much more than what dose you take, and don't fucking overeat especially in the 5 weeks after stopping it, or you're speedrunning perma fucked brain damaged obesity.

>>77208974
>>77208977
>>77209043
I know the starting dose is 4/6mg but that's way too fucking much bro. Also I live in Australia so finding a source is difficult unless you can suggest somewhere.
>>77209971
>>77210054
Semaglutide is prescription in Australia and literally hundreds of dollars more though a GP and no GP is gonna prescribe a thin person semaglutide. Reta isn't approved for human use yet so it's free to buy from peptide sites and isn't going against current regulations.

QUESTION TO PEOPLE ON RETA: Do you have problems with food sitting in your stomach for a long period of time undigested?

>>77210054
Thank you for sharing all this, I'll just throw it away
I just wanted an easy cut on chicken and potatoes, but I'd rather have a difficult cut than risk being an uncontrollable eating machine later on

>>77208977
Doesn't help by saying how to get it at reasonable cost. Fucking roid tranny faggot.

fucking newfag retards stay the fuck away from my peps

>>77210079
If you’re having that issue on repa, a common solution is to drink 1/4 a shot of bleach before every meal. It will help the food melt down in your stomach, to be easier for your colon to process. People will tell you not to drink bleach but they’re always failures with weak bodies.

>>77208998
>>77209971
Could you please post some sources on this?
I don't mean this in a "I don't believe you" way, I actually understand all of what you wrote and I'm just interested in reading up more on this. I did some research and wrote a bit of a review on the use of GLP-1r agonists vs SGLT2i for cardiovasculart risk mitigation a couple of years ago in college but I haven't kept up with the literature since then. One of the sources I used was the article you posted the image from, actually, so it'd be interesting to complement this with new information and take retatrutide into account.

>>77210070
>>77210091
>>77210098


grey market, low dose semaglutide is so cheap its basically almost free.
No concerns with the GIP agonism thing either

>>77210131
>grey market
Dude you're talking to someone who has no idea what this is or how you access it.

>>77210128
Sure, I'll post some of the sources I can remember reading off the top of my head.

Heres a couple that describe how GIP induces hypothalamic inflammation
https://link.springer.com/article/10.1007/s40618-025-02719-w
https://academic.oup.com/endo/article/161/9/bqaa102/5865317

The most worrying sign I think is the increase of SOCS3, which directly blunts leptin sensitivity.
I don't have a source that I can remember that says SOCS3 blunts leptin sensitivity though

I've read a lot of papers on the differences between GIP agonism & antagonism, and tried to apply the findings to lean and insulin sensitive individuals. These were great papers
https://www.nature.com/articles/s42255-025-01294-x
https://www.sciencedirect.com/science/article/pii/S2212877820302131
https://journals.physiology.org/doi/full/10.1152/ajpendo.00460.2007

There was another really good one discussing how chronic pharmacological GIP agonism could lead to functional antagonism, I'm trying to find it, but they concluded it was possible but probably not the best explanation as to why agonism/antagonism both produce weight loss

This is a great comparison of the signalling bias of different ligands and receptors
https://cf-ecom.eurofinsdiscoveryservices.com/wp-content/uploads/2024/02/Eurofins-Discover_ObesityLITE_SLAS-2024-1.pdf

The studies on GIP knockout mice are an interesting read too, not sure if this is the paper Im thinking about, but it does a good job at comparing
https://journals.physiology.org/doi/full/10.1152/ajpendo.00646.2020

>>77210167
Many thanks anon, looks like these will be some comfy reads.

>>77210218
Are SGLT2i's good for your heart by the way?
I take 12.5mg empag/ day prophylactically for kidney health

>>77210227
Possibly, but most evidence of benefits is in patients with pre-existing cardiovascular disease. Some studied mechanisms could also apply to healthy individuals.
They have a mild diuretic effect but seem to mostly reduce intersticial fluid instead of intravascular fluid like other diuretics, and this limits the magnitude of the neurohumoral stimulation associated with volume contraction.
They also slightly shift myocardial metabolism towards ketones, so the heart is less likely to be in an energy-starved state as it has more options to rely on for energy.
Finally, they seem to have an anti-inflammatory effect that acts directly on and attenuates extracellular matrix remodelling and fibrosis.
Animal studies have also shown reductions in sympathetic tone, protection against reperfusion injury, and increased EPO secretion, but none of that's been studied in humans as far as I know.

In short, they might provide some protection against myocardial remodelling and heart failure.

>>77210248
I see, that seems pretty positive and promising. thanks for sharing

>>77210070
4 or 6 is not the starting dose, that would probably cause your resting heart rate to explode. But 8mg is a moderate dose to.work up to over a few months. Australia is tricky so I'm going to help you out. Can't post source because jans will delete thread and also never accept any direct source links anyway, its usually a scam
>Stairwaytogray DOTcom
>scroll down join telegram
>vendor promos
>search term Australia
>vendor that ships to Australia and offers reship insurance for 20% fee, starts with a J
>They have Sema and triz
>1 kit of 20mg tirz, so 200mg total which should last you at least 6 months, but realisticly 9, should run around $80 plus insurance plus shipping =$150ish usd
>only use the contact email listed in the vendor promo, anyone else that contacts you is a scam
>>77210079
Slowed gastric emptying is one of the mechanisms of action for glp1s, so that's normal. If you.overeat it can be very uncomfortable. If you're constantly vomiting then gastroparesis is possible, stop taking and maybe go to urgent care or the ER

>>77208965
Exchange current routine with hundreds of reps of bodyweight exercises every day (well, work up to this, you'll be sore permanently). 100-250 reps per set is a good, if rough, goal. I'll wanr you though, you will lsoe all explosive strength, you won't be able to sprint or jump to any meaningful degree. But boy, you will burn through fat like a crazy ass motherfucker as soon as you hit a certain threshold after a few mweeks or months of this. Ottermode Olympus, basically.

Usually, I advise against this because it's really bad for performance outside of high reps (or maximal strength, funnily) because it really kills all speed for some reason. But if you just want to stay fit and lean and you wanna eat whatever you want, and nothing else, I guess it's perfect.

Just do a max set of push ups and sit ups and squats every day upon waking up. do the main wokout in the afternoo0n or evening, also every day, 3 sets each of the usual calisthenics for high reps. just get the reps in, dgaf about rom. 30-60 sec between sets.

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>>77208965
>175cm
>73kg
>15% bodyfat
>2026
>doin' GLP-1 hammy pepes
Niqqa wut u supposed to be bulkin'. I frame-mog yo ass by like 10cm and 20kg with lower bodyfat, don't even shoot up these weird scam vials and be on small molecule glucose disposal agents n shit instead.

>>77210404
>small molecule glucose disposal agents n shit instead.

>eat glucose
>take drugs to get rid of it instead of using it in physical/mental tasks or not consuming it in the first place
Mental retardation.

>>77210393
Bro one look at reddit and there are dozens of threads from Australians all saying how their overseas shipments of peptides have been seized by customs. I live on an Island it's not like someone can drive over the border with 1 million vials and start distributing. Also, I wasted a bunch of time downloading telegram and I'll have to find a way to linking a fake phone number to the telegram account, and then try to figure out how to buy cryptocurrency, all to order some shit online which could easily just be seized by border force and I'll never have any way of knowing

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>>77208965
>Has anyone experienced this?
being an american? No, you wouldnt know how it feels, simply cannot imagine

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>>77209336
… which it is

>>77210131
>Just go in the Grey market bro
You sound like a fucking retard and once again gabe zero info fucking roid tranny faggot

>>77208965
Spam thread. You cant be paying this much. I source at less than $0.50/mg. At 60 weeks i am at 5mg/week. 5' 11" 198. Reta is cheaper than the crap food I no longer care to eat.

>>77208998
Fuck this nigger. If you are 50+ lbs overweight, you are open to metabolic cancer, arthritis, liver disease, heart disease, brain damage from high blood pressure. Just having the weight off is a game changer. Retatrutide arrested my arthritis in 24 hours and gave me a working foot. From there my training increased. In 48 weeks I lost 50lbs and adopted a healthy life, ate better, stopped using alcohol, in gym 5x week. I skip,dip,squat and I look fit. I dont care about miniscule and unproven outcomes of the far future, when I have made lasting changes to stop known and proven health risks today. Demotivation posters eat shit. I dined with a beautiful woman outside in perfect weather, and looked good doing it. I feel awesome. Not going to worry about a future I would never have lived long enough to see. Got sit in corner if you dont like it you fat blob eyesore

>>77209204
Post body. You wont.

>>77209727
The phase two trial had some participants at 4mg starting. Other research started at 2mg. I started at 1mg. 1mg per week helps you recalibrate your habits and avoid side effects from too much too soon. 1mg reta a week for a beginner. No need to rush. Enjoy the ride.

>>77210054
I am going to have some oats with almonds and cranberries, then shoot 5mg reta, then go to gym, just some cardio today. Reta gave me my life back. You do you, a nigger without a citation.

>>77212206
"You should avoid retatrutide if you're lean and insulin sensitive."
>if you're lean and insulin sensitive
>lean
>insulin sensitive

"If you are 50+ lbs overweight"
>50+ lbs overweight
>lean and insulin sensitive

And thats why they call it Retard-trutide everybody

>>77210079
Delayed gastric emptying is a feature, not a bug. Goodbye food noise.

>>77210165
Grey market just mean a channel for something not approved by those who approve. Its not an actual marketplace. There are discord channels on this subject. Get some agency and no, im not going to blow up my source.

>>77208965
I bought reta 10mg recently and it was about what you paid OP, maybe a little under. I got it from a top reviewed site from eroids. Hasn't arrived yet so can't comment on its effectiveness. Don't let these faggots tell you you got scammed. Yeah sure, they get glp1s for much cheaper, but conveniently leave out where they're getting it.

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>>77210409
Keep shitting on "biosharting trannies" while I can gobble a whole case of icecream bars without turning into a hammy or getting insulin resistance, Chud.

>>77209971
How fat is an obese person to you? I'm about 70lbs overweight so I got reta. My goal is to drop down to 220 and from there give my body a break and just increase workout volume.

>>77213389
Fine, i see your point.

>>77210070
you just literally responded to the guy giving you a source retard

>>77208965
>retardputride
Ngmi

>>77210227
don't forget to wipe your pisshole well if you don't want an infection

>>77210499
Have you tried eating less?

>>77213389
but .. why would you want to do that. Were you fat as a kid or something, I'm personally just not into sugary shit

>>77212222
wiped his brown zoomerino ass

>>77210018
Don't listen to this chat gpt retard lol. Reta is insanely good for health, it melts visceral fat and can reverse non fatty liver disease.

>>77208965
>15% body fat
>still unhappy
You have body dysmorphia. More drugs won't help.

>>77213857
>drug with no longer term clinical trial and unknown long term side effects
>good for health
You are retarded.

>if I reach 10% bodyfat finally women will want to have sex with me

Sorry, no. You will just feel like shit and be starving all the time, while remaining a nofunallowed dieting freak.

>>77208965
Oh shit, it's real, I thought it was a joke because it was called retarditude

>>77208965
they should start calling it retardutride, because you have to be a real retard to take this

>>77208998
Can you translate this into English for a brainlet?

>>77210167
https://doi.org/10.2337/dbi21-0001
even in Fukuda's own review, at the end of every section he pretty much says
>idk why these in-vivo studies dont support in vitro bullshit from my lab
>In contrast to its assumed obesogenic role, GIP does not promote food intake or adiposity. Instead, negative energy balance is induced by administration of long-lasting GIP derivatives or transgenic overexpression of GIP. In addition, GLP-1/GIP hybrid peptides have been shown to induce marked weight loss in preclinical and clinical settings. The therapeutic efficacy of this combination is superior to that of GLP-1 receptor agonists alone, suggesting that GIP agonism has weight-reducing effects in a pharmacological context.
>Of note, supraphysiological dosing of a long-lasting GIP agonist has an opposing effect on neural inflammation. In the context of neurodegenerative diseases, peripheral administration of long-lasting [D-Ala2] GIP derivatives (2,500 pmol/kg/day) significantly reduces the activation of microglia and astrocytes in the CNS (59). Further, a dual GLP-1/GIPR agonist more effectively reduces proinflammatory cytokine levels in the brain in a mouse model of Alzheimer disease than the GLP-1R agonist alone
>Conversely, GIP analogs or GIP/GLP coagonists seem to induce several neuroprotective effects, including stimulating progenitor cell proliferation in the hippocampus, improving learning and memory, and enhancing synaptic plasticity in animal models of Alzheimer and Parkinson disease

>>77208990
CICO deniers are all fatasses. No exceptions.

>>77213908
Same. I couldn't unsee the retard.

>>77208965
If you wanted to starvemaxx you should have bought tirzepatide.

Reta lets you eat, tirz blocks all food
Noise. I bought 300mg for $500.

Why do you need a peptide to lose weight at 5'9 160? What the hell is going on?

>>77208965
>Retardicide

>>77209367
the psople behind this need to be round up and lynched

>>77208965
Our response REDDITRUTIDE bros???

>>77215146
Only do REDDIT-RETARD-ICIDE if you're a hamplanet powershitter who has a lot of excess fat AND muscle to lose. Not if you're normal weight or just a bit overweight trying to recomp.

>>77209709
This already happened to me I think. I get very strong hunger when off Ret. Am I fucked

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>>77208965
>this shit costs me $110 per 10mg

It should be costing you $112 per 100mg, you're paying a 900% markup my man

>>77208965
I cut at 1400 cals / ~180-200g protein / 40-50g fats / ~50g carbs and I rarely experience any sort of hunger despite being like 1500-1600 deep into deficit. No matter the circumstances getting hooked on a fucking reta to maintain 15% sounds retarded, you'd benefit much more from keeping your diet in check, you definitely won't be starving by eating enough to maintain 15% bf.

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>>77216520
I followed that guy's advice and look on telegram and people in my country are literally going to jail for buying ozempic from china and none of the sellers are even shipping there anymore.

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>>77213902
Okay yes that is a problem, the border is closed pretty hard.

>*Due to Australian customs regulations, Standard shipping method is not available. -2026-02-12

The people being arrested though are dealers with a whole operation, not consumers. Is there even one case of Aussie police arresting a user and not a seller?

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>>77216997
Damn reading the rest of this note from a vendor that does, technically, ship to Australia, but for $90 USD and they're putting all customs paperwork liability on the customer.

> *Due to Australian customs regulations, Standard shipping method is not available. -2026-02-12
> The expedited shipping option for overseas delivery is shipped individually by the carrier, allowing for faster transit in many cases. However, please note that you may need to handle customs declaration procedures yourself, including any unpredictable customs fees. If you need assistance, we’re always happy to help and can provide any required documents, such as proforma invoices.
> Once an order is placed, our logistics department will prepare and pack it within 3-5 business days. If your package is detained by customs, we can reship the order once at no additional cost.

>>77208965
two seconds of internet research would show that you need to titrate up reta every few weeks. you started at a wicked low dose. by now you should be closer to 6-8 mg/week. The studies for Reta show that it is the most effective for fat loss (not weight loss) for a one-year period, but test subjects who had the most success titrated up to 12mg/week.

>>77217528
>>77217539
yea this is why I'm getting price gouged buying from Australian resellers at $110AUD for 10mg
>>77218179
Mate the whole point was for the retatrutide to reduce my cost of living and allow me to cruise at a healthy low bodyfat given my unavoidable sedentary lifestyle and horrific work hours. I pay $5500 per month on a mortgage, fuel is $2.30 per litre, I have a $32000 student debt, and I make $32 per hour. Groceries are fucking expensive and the $11/week I was 'spending' taking 1mg reta was saving me like $50 per week on groceries.

If I took 8mg/wk I'd literally be spending $90 per week

>retarditude

>>77218943
I found a research chemicals lab that sells and ships from a warehouse in Australia, anon. Did you check the glp1forums? Because one of them advertises a global warehouse network.

Prices cheap as fuck.

>>77212206
REDDITRUTIDE BROS WHY SO MAD?

>>77221000
According to telegram all shipping from china to aus is suspended and anyone in aus is fucked for the time being

>>77221145
That's "shipping from china." If the vendor's own warehouse is in Australia, then AU customers are not shipping from China.

The only question is if their Australian warehouse is out of stock or not, or has trouble restocking in the long term.

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>>77221145
>>77221266
Unless this is a scam it looks like they're still in stock despite the troubles people have with customs.

>>77221266
They get all their 'warehouse' stock from china and their 'warehouse' is gonna be some chinese guy living in melbourne who has 10000 vials in boxes in his apartment.

I emailed a vendor called HPT Peptides off GLP1forums that was only only one I could find using the search function which said australia warehouse.

>>77221280
Correct, and until they run out of stock and need to import more, they're a perfectly viable option. So Aussie cunts need to stock up before it sells out or prices hike.

>>77221280
None of that contradicted literally anything in the post you're replying to.

>>77221273
wtf is this page? all if found on glp1forums was some shitty telegraph number of 1 seller

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>>77208965
My wife's been using this stuff for a bit, but she gets inflammation on the injection sites. It goes away in a few days, but it has me concerned. Any thoughts? We've tried two different sources.

>>77218943
that sounds like a you problem. if you can't afford quality drugs at a large quantity, don't do them.

>>77221351
Are you using insulin needles? I would first check for air bubbles, that's usually the biggest culprit for injection site inflammation. Otherwise, slow down the injection. If you're doing 50 ml, count to 10 for the whole injection. Also mix up the injection sites.

>>77221689
I meant 50 iu, not 50ml. that would be crazy.

>>77221342
Could be a scam site or the personal site of a legit rep. Seems strange they advertise accepting credit card, most peptide vendors are blocked by cc processing companies unless it's alipay subterfuge. Always safer to use the public contact info on glp1forums, stg or meso

>>77221351
Injection site reaction is a common side effect even with pharma autoinjectors/ quick pins. Check the zepbound and mounjaro subs on reddit. Use hospira and take a benadryl

Advice for coming off of it when I am done losing?